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KMID : 0383119920400010087
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Journal of Aerospace Medicine
1992 Volume.40 No. 1 p.87 ~ p.100
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Effects of graviational stress on immune response in mice
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Park Young-Min
Lee In-Kee
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Abstract
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A number of studies have suggested that gravity changes may influence immune functions we wished to evaluate its effect on immunity by analyzing the change in blastogenic activity to concanavalin (Con A) as well as the change in the number of CD4+ and Cd8 + T cells in mice. Experimental groups of mice were sub - j -ected to a grayitational stress of +15Gz for 40sec/time(2 times/day) for up to 14 days. Con A-induced proliferation assay and T cell subsets analysis of thymic and splenic lymphocytes were performed 24 hr after last stress exposure. Short-term exposure to the gravitational stress clearly enhanced the Con A-activated T cell proliferation,while depression occured with loger exposure. CD4+and CD8+T cell percen= tages were in the range of normal values after gravitational stress. More interestingly, when data are expressed as the ratio between CD4 +and CD8+cells, no consistent abnormalities in the relative proportions of the T cell subsets were noted. These observations would seem to indicate that gravitational stress not only can enhance immune responsiveness but can also depress in accordance with duration of stress.
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KEYWORD
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